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Semaphorins are a large family of proteins that function as guidance cues for axonal/dendritic projections.
Throughout their migratory journey, which in mice starts at embryonic day (E) 10.5 and is complete by birth, many factors function as guidance cues.
Seven groups were based on molecular function prediction by using the FunCat annotation scheme [ 21] and the predicted molecular function as guidance.
Indeed, several cell adhesion molecules previously thought to function as guidance cues have recently been shown to exert 'non-cue' functions cell-autonomously (Petrovic and Schmucker, 2015) and through implementing simple developmental rules (Hassan and Hiesinger, 2015).
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To the best of our knowledge, little work has been reported from cheminformatics study for these especially pairwise datasets, which may provide insight into the mechanism of actions of the compounds and relationship between chemical structures and functions, as well as guidance for lead compound selection and optimization.
Ephrin Eph signals function as topographical guidance cues for neurons [26], [29], [37] and synaptogenesis and plasticity of synapses in the central nervous system [38].
In addition to patterning, BMPs also function as axon guidance molecules.
Wnts are morphogens that can function as axon guidance cues (Salinas and Zou, 2008; Clark et al., 2012; Salinas, 2012).
Sema4A belongs to a family of glycoproteins that were originally found in the nervous system and that function as axon guidance molecules.
Wnt proteins are a family of morphogens that have recently been shown to function as axon guidance cues (Salinas and Zou, 2008).
These vehicles are equipped with a variety of functions such as guidance and routing systems to traffic management and load transfers.
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