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PREs are several hundred base pairs long stretches of DNA without a clear consensus sequence but predicted to function as clusters of binding sites for DNA-binding proteins.
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In addition to the entire set of Gaussians embedded in the HMM, a fairly small set of Gaussians are trained to function as cluster Gaussians (CG).
Finally, the data was clustered by using the non-hierarchical K-means clustering for genes, which identifies k points that function as cluster centers.
The C-terminus of Msn2p contains four arginine- and lysine-rich clusters that function as a classical NLS [ 128].
Once appointed the node functions as cluster head till its duration timer expires.
Thus, the expected result is that the maximum Δ would be at a single cluster, and that Δ would be essentially a decreasing function as more clusters were added.
Moreover, newer developments that complement traditional mapping functions such as cluster and contextual analyses can be very useful adjunct investigative tools in outbreak control, as our example on SARS in Hong Kong has highlighted.
We hypothesize that this central pathology revolves around dysfunction of hypothalamic nuclei, producing conditions in which the painful attacks can arise or perhaps that these nuclei function as a "cluster generator".
One of these BchL cysteine residues (Cys) is conserved in HCF101 (Cys), yet might have lost its function as a cluster ligand.
The third step is to enrich gene clusters with higher probability to function as SMB gene clusters via synteny analysis (Fig. 1e).
However, these two tools only focus on simple functions, such as clustering homologous genes and gene curation.
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