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However, it is possible to design a substrate strand that can function as an effector molecule for another allosterically controlled ribozyme, for instance in the design of a cascade of nucleic acid computers.
It may function as an effector molecule of innate immune system [58], [60].
We and others previously have shown the LRP6-ICD can function as an effector of the Wnt pathway by attenuating GSK3β mediated β-catenin phosphorylation thereby enhancing cytosolic β-catenin stabilization [35], [36], [37], [38], [39].
Similar to HESP767, Ps87 may function as an effector or avirulence factor during wheat infection in P. striiformis f. sp. tritici.
To investigate how AGO18 acts in antiviral defense, we first tested whether this protein may function as an effector of vsiRNAs, like AGO1.
In the flax rust fungus, HESP767 is expressed in haustoria and may function as an effector in interactions with the host plant [ 41].
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These data indicate that MIWI2 functions as an effector of de novo DNA methylation of the retrotransposon.
Our observations suggest that TXNL1 functions as an effector of oxidants or redox sensor that couples oxidative stress to endocytosis, by converting redox changes into a specific GDI∶Rab5-mediated endocytic response (see outline, Fig 5).
We thus conclude that TXNL1 functions as an effector of oxidants or a redox sensor that selectively couples oxidative stress and redox changes into GDI∶Rab5-mediated response in fluid phase endocytosis.
We attempted to determine this by manipulating the Suppressor of Hairless [Su(H)] activity with mRNAs encoding either the dominant-active form of X-Su(H /Ank or the dominant-negative form of X-Su(H DBM [32], The Su(H) is a component downstream of Notch signaling and functions as an effector to prevent receiving cell from adopting a default cell fate.
10.7554/eLife.05733.010 Figure 3. AGO18 unlikely functions as an effector of vsiRNAs.
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