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MLKL is a kinase-like protein and functions as a substrate of RIP3.
For example, Par6 was shown to interact with TGF-β receptor and function as a direct substrate of TGF-βRII.
CRBN functions as a substrate receptor of the Cullin4 (Cubiquitin E3 ubiquitin ligase complex.
Although few BTB-Kelch proteins have been demonstrated to function as a substrate adaptor for a E3 ubiquitin ligase, BTB-Kelch proteins have been demonstrated to have other functions not related to being substrate adaptors of E3 ubiquitin ligases.
Heir, P. et al. DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase.
The gene product of ilvC functions as a substrate ambiguous reductase in branched chain amino acid biosynthesis and pantothenate biosynthesis.
The mechanism by which niacin reduces oxygen toxicity may involve the ability of niacin to function as an alternate substrate for NAD synthesis.
Saposin B may also function as a transporter of lipid substrates to these enzymes (15).
As a substrate for the sirtuin family of NAD+ dependent deacetylases, known as silent information regulators of gene function [27].
F-box/LRR-repeat proteins function as substrate recruiting subunit of SCF-type Ubiquitin E3 ligases [ 67].
E3 enzymes function as the substrate recognition modules of the system and are capable of interaction with both E2 and substrate.
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