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Together, our data indicate that RNase III may function as a sequence specific RNP complex and reveal a new approach for the regulation of nuclear RNA.
A basic helix-loop-helix leucine zipper (bHLH/LZ) protein, Myc dimerizes with another bHLH/LZ protein, Max, to function as a sequence specific DNA-binding transcription factor 10, 11.
This observation suggests that TARE 5 may function as a sequence boundary element separating telomeres from coding regions.
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Splicing factor SRSF10 is known to function as a sequence-specific splicing activator that is capable of regulating alternative splicing both in vitro and in vivo.
SRSF10 is known to function as a sequence-specific splicing activator [ 63] and can promote both exon inclusion and exclusion in chicken cells [ 64].
Previous studies suggest that only one of the motor domains is active as a helicase and the other has evolved to function as a sequence-dependent DNA-binding moiety, essential for the recognition of Chi-sites during strand resection [ 26– 28].
More generally, the present study emphasizes the usefulness of investigating function as well as sequence evolution in a wide range of organisms to interpret functional studies in a single species.
The fusion protein functions as a sequence-specific DNA methyltransferase protecting DNA against digestion by the EcoKI restriction endonuclease.
In RNA-induced silencing complexes, the small RNA functions as a sequence-specific guide that directs AGOs to fully or partially complementary target RNAs through base pairing interactions.
The p53 protein is a tumor suppressor that functions as a sequence-specific transcription factor regulating the expression of various target genes involved in apoptosis, cell-cycle arrest, DNA repair, senescence, and inhibition of angiogenesis and metastasis.
The protein encoded by the homeobox B4 (HOXB4) gene functions as a sequence-specific transcription factor that is involved in development, and the transcription factor paired box 3 (PAX3) may play a critical role during fetal development.
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