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A modified gradient method is used in the finite-element context to successively add pieces of constrained damping layers at the elemental positions showing the steepest gradient of the goal function as a result of the treatment.
Even though protein homologues may be functional with the mutated residue at the given position, even subtle differences in protein structure could result in vast differences in function as a result of the mutation.
However, such potential drugs may still have major effects on cellular function as a result of the lowered capacity of the thioredoxin system, reminiscent to the effects of knocking down TrxR1 expression by siRNA [60], [68], [74], [75].
The mechanism(s) underlying reduced bone resorption are unclear but could speculatively be due to impaired osteoclast function as a result of the exceptionally elevated levels of FGF23.
Survival is not only limited by tumor progression, but also by deterioration of liver function as a result of the underlying liver cirrhosis.
Possible changes in dopamine function as a result of the deletion of the snca gene might give rise to the low impulsive phenotype seen in H and KO mice in the present investigation.
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The mutations result in a loss-of-function as a result of the synthesis of a non-functional protein, altered protein trafficking, or change in gating.
Catholic hospitals--like virtually all other hospitals in the Unites States--are only able to function as a result of a swath of government handouts and subsidies.
These results indicate that PEG-HCCs do not alter major functions of macrophages, likely as a result of the inability of these cells to internalize the nanoparticles.
"Even if there is no ovarian function as a result of chemotherapy, a woman can carry a pregnancy," she said.
An episode of sudden deterioration in allograft function as a result of either antibody-mediated rejection or T cell-mediated rejection, which result from different molecular processes.
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