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NO increase due to alcohol intake may function as a protective mechanism preventing bone resorption in cases of estrogen insufficiency.
Acute pain serves a useful function as a protective mechanism that leads to the removal of the source of the pain, whether it be localized injury or infection.
However, the autophagic response can also function as a protective mechanism allowing the recycling of proteins and cellular components to survive cell injuries induced by cytotoxic agents.
While some initial studies described autophagy as a tumor suppressor mechanism [16], the autophagic response can also function as a protective mechanism allowing the recycling of proteins and cellular components to facilitate cell survival during the severe cellular stress of cytotoxic therapy [17].
In some reports, autophagy appeared to function as a protective mechanism against cellular stress.
Both S-nitrosylation and S-glutathionylation cause a decrease in ATPase activity and are reversible post-translational modifications; thus, the S-nitrosylation of complex I can function as a protective mechanism.
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The results together suggest that activation of Src/STAT3/HO-1/autophagy pathway functions as a protective mechanism to antagonize the cytotoxicity of DOX in the MDA-MB-231 cells.
As shown in Figure 2 d,e), knockdown ATG5 levels blocked the induction of autophagy, while increasing the sensitivity of MDA-MB-231 cells to DOX treatment, indicating that autophagy functions as a protective mechanism in antagonizing apoptosis induced by DOX.
Our current data suggest that stimulation of IFNAR1 downregulation during pancreatitis functions as a protective mechanism that limits the extent of tissue damage and promotes the transition of inflammatory process to the stages of tissue regeneration.
Although the HPA axis functions as a protective mechanism to maintain allostasis, intense chronic activation is believed to lead to permanent derangements of the HPA axis and increased susceptibility to disease.
Our analyses suggest that AMPK regulation of Ca2+ and SERCA activity could be through phosphorylation of CALNX Ser-247 and/or Thr-93, functioning as a protective mechanism (Additional file 2: Figure S1C).
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