The center currently functions as a probe modification facility, a source of novel probes (and other technologies), and as a location at which these tools can be applied to answering essential biological questions.
An alternative but more practical way is to mix equal molar quantities of probes each labeled with a single but different colors to function as a single probe set labeled with different colors.
In some cases, the TOL heuristic might function as a positive probe in which it connects together local phylogenies; in others it might be used as a negative heuristic, when researchers use the TOL to seek phenomena to which it cannot apply (much of the HGT research, for example).
Collectively our results are consistent with activation of Rho/ROCK, but not Rac1, mediating increased translocation of ExoS-WT in highly metastatic MTLn3 cells, and highlight the ability of Pa ExoS-GAP activity to function as a biological probe to detect alterations in MTLn3 cell properties linked to metastasis.
The rebuilding of luminescence was highly selective to S2− over other common anions, which allowed L function as an "on off on" probe for Cu2 + and S2− alternately.
We evaluated whether Lpa could function as an inducible probe of α-ketoacid dehydrogenase inactivation using E. coli as a model system.
Furthermore, using standard Western blotting protocols, we demonstrate that ATRX-ADD can function as a highly specific probe to detect endogenous H3K9me3 from cell lysate, showing sufficient affinity and specificity that rivals the corresponding antibody (Additional file 7: Figure S5).
The results indicated that the magnetic/fluorescence micelles could function as an efficient imaging probe.
The GIRO labeling system functions as a "smart-probe" distinguishing and reporting protein localization simply based on color in live cells.
