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Studies have revealed that CNGCs may function as a pathway for Ca2+ conduction into the cytosol as an early event during pathogen defense signaling cascades [ 15], and plant response to other biotic and abiotic stresses [ 16].
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This gene codes for the AhR repressor and is a component of the AhR signaling cascade, where it functions as a pathway inhibitor.
Autophagy also functions as a pathway for the turnover of ER membranes and contents in response to ER stress in Arabidopsis.
The Ssa2p-mediated pathway may function as a regulatory pathway for tRNA import to adapt nutrient stress by using the heat-shock protein in a novel mode of action.
"This suggests that apprenticeships are currently not functioning as well as they could as a pathway into social care for young people," concluded the report.
By identifying GABAergic function as a crucial pathway influenced by the expression of pathological tau, we may in the short-term be able to take advantage of several FDA approved drugs regulating GABAergic function for use in AD treatment.
In established tumors, autophagy can function as a prosurvival pathway in response to metabolic stresses such as nutrient deprivation, hypoxia, absence of growth factors and the presence of chemotherapy or some targeted therapies that might mediate resistance to anticancer therapies.
It was recently reported that ΔNp63 α can transcriptionally repress Nedd4 [ 40], suggesting that downregulation of Nedd4 may function as a feedforward pathway to increase ΔNp63 α intracellular concentration under certain circumstances.
Since L-arginine in mammals is derived mostly from renal de novo synthesis and dietary intake, CAT1 at the BBB would function as a supply pathway for L-arginine to the brain.
The intrinsic pathway can also be activated by thrombin itself, and this system may function as an amplification pathway in sepsis-induced disseminated intravascular coagulation [ 47].
These results also suggest that if the damaged mitochondria cannot be repaired by MALM, MIVs function as an alternative pathway in mitochondrial quality control by eliminating the unhealthy mitochondria.
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