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In our analysis of FXR binding to hepatic chromatin, we showed that LRH-1 could function as a partner transcription factor for FXR on a small set of target genes through binding to a nuclear receptor half-site that was co-enriched with the FXR IR-1 element on a genome-wide scale [ 14].
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In addition, SERBP1 functions as a partner with the progesterone receptor membrane component 1 (PGRMC1) in mediating the anti-apoptotic action of progesterone on the female reproductive tract of humans [ 53].
HER2 functions as a partner with other HER receptor family members in the formation of heterodimers, which initiate signaling through several key pathways that are known to drive proliferation and survival in epithelial cancers [ 11, 12].
Todd Oldham Studio, for which Linda continues to function as a business partner, was reorganized to become a multifaceted design company, developing home furnishings for clients like Target.
Here we show for the first time that a small soluble lectin, human galectin-1, one member of a large galectin family, can function as a fusion partner to produce soluble folded recombinant human glycosyltransferase, β-1,4-galactosyltransferase-7 (β4Gal-T7), in E. coli.
Hence, it could function as a helicase partner for either the REase or pPIWI-RE or both.
The best known function of cyclin D1 is most likely its catalytic function as a regulatory partner for the cyclin-dependent kinases (CDKs) 4 and 6.
This gene is upregulated under soybean iron stress conditions, and is thought to function as a binding partner for FIT [ 14].
The activated HER2 is therefore generally co-expressed with at least one other activated HER receptor that has the capacity to function as a dimerization partner.
Because loss of GLRX5 causes mitochondrial iron overload, and GLRX5 might function as a BOLA3 partner (Huynen et al., 2005), it seems likely that the mitochondrial iron overload phenotype will also be observed in this newly described disease.
In addition, we identified other predicted proteins encoded in fungal and amoebal genomes that may function as (a) binding partner(s) of the Nox activator proteins (described below), suggesting the early evolutionary origin not only of the activator protein, but also possibly of a rudimentary organizer subunit.
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