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The stromal stem cells in this second group function as a niche to recruit and store the incoming blood stem cells and retain their stem cell activity throughout life.
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Several reports have shown that a hematopoietic environment comprised of stromal cells functions as a niche to support hematopoietic cells.
These findings indicate that the human MSC-derived ossicles function as a hematopoietic niche and may potentially serve as a re-engineerable platform to study normal and diseased human hematopoiesis in a physiologically optimized environment.
The adipose vasculature has been proposed to function as a progenitor niche and might provide the signals for adipocyte development (Tang et al., 2008).
Our transcriptional profiling study identifies the LEC as a preferential site for limbal SC with some characteristics suggesting that it could function as a 'SC niche' supporting quiescent SC.
The authors also proposed that glomerular PECs could function as a progenitor cell niche for podocytes and under proper settings could proliferate and transdifferentiate into podocytes, which may be a pivotal factor for the regression of DN [ 31].
Progenitor cell maintenance at late developmental stages is also dependent upon Hedgehog (Hh) signaling from a small population of cells called the posterior signaling center that functions as a hematopoietic niche (PSC) (Lebestky et al., 2003; Jung et al., 2005).
While the transition literature has traditionally treated existing infrastructure as a barrier, recent research has emphasized that infrastructure transformation can function as a facilitator, helping sustainable niche technologies break through.
But, on top of utilitarian functions, this technological future could offer even more experimental and bespoke objects that function on a niche level.
This result suggested that disruption of SSC function as a result of architectural changes in the postnatal niche is reversible and that the seAip1−/− mice could serve as a good model to study the underlying mechanisms.
The posterior signaling center (PSC) functions as a supportive population (a niche) that expresses Hedgehog (Hh) and maintains the progenitor cells utilizing this 'niche signal'.
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