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Our findings of deletion in the SLC25A43 gene together with varied SLC25A43 protein expression in HER2-positive breast cancers supports the role of altered mitochondrial function as a hallmark of cancer.
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Indeed, declining hippocampal size and function is a hallmark of Alzheimer's disease.
Declining β-cell function is a hallmark of T2DM progression 22.
However, pathological, excessive synchronization may strongly impair brain function and is a hallmark of several neurological disorders.
As a hallmark of higher cortical function, cognitive control allows flexible behaviors and adaptations to changing environment.
Loss of normal tight junction functions constitutes a hallmark of human carcinomas.
Nuclear foci have been considered as a hallmark of RNA gain-of-function toxicity.
Social disability refers to difficulties with social and occupational functioning (i.e. difficulties engaging in meaningful activities and relationships), and has been described as a hallmark of severe mental illness.
Other lines of evidence also point to mitochondrial dysfunction as a hallmark of aging including mtDNA mutations and the inability of mitochondria to maintain normal function in the face of gradual age related stress and damage [ 1].
DNA replication stress as a hallmark of cancer.
Winnicott sees this selflessness as a hallmark of successful mothering.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com