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Probing the interactions of the DNA mismatch repair protein MutS with altered and damaged DNA is of great interest both for the understanding of the mismatch repair system function and for the development of tools to detect mutations.
German physicist, winner with Bert Sakmann in 1991 of the Nobel Prize for Physiology or Medicine for their research into basic cell function and for the development of the patch-clamp technique, a laboratory method that can detect the very small electrical currents produced by the passage of ions through the cell membrane.
Quantitative analysis of tumour vascularity is of paramount importance for the assessment of microvascular function and for the development of novel antivascular treatment strategies.
These studies provide a powerful new tool for analysis of neurofibromin function and for the development of therapies for a common human disorder.
Germ-line transformation of insects is now a widely used method for analyzing gene function and for the development of genetically modified strains suitable for pest control programs.
Anyway, more investigations about BmooMP α-II are needed to elucidate the mechanisms of inhibition and may contribute to the basic studies of B. moojeni venom of platelet function and for the development of novel therapeutic agents to prevent and treat thrombotic disorders.
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Taurine is a key amino acid for cardiovascular function and for the development and function of skeletal muscle.
A novel role for caveolin-1 in B lymphocyte function and the development of thymus-independent immune responses.
Immune function is the target for the development of functional foods.
Further knowledge of Treg cell development and functions is absolutely essential for the development of an effective therapeutic tumor vaccine.
Better right ventricular function is a risk factor for the development of severe primary graft dysfunction.
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