Although allowing for some degree of sub-functionalization of protein function, alternative transcription/splicing does not completely relax the constraints imposed by pleiotropy.
Essential for protein function, alternative splicing appears also to be determinant for the regulation of transcript abundance; it can indeed reduce gene expression by yielding isoforms that are degraded by non-sense mediated decay or other mechanisms [10].
Many of the sites involved in a coevolutionary relationship in a bacterial group have been reported to be involved in a GroEL function alternative to protein folding.
Over time, the name has lost its punny puckishness much as the movement has steadily shifted from a proudly anacharical – even populist – response and rebellion within the GOP to a smoothly functioning alternative to it.
* KODAK Theatre HD Player: Owners of the highly acclaimed KODAK Theatre HD Player can use the Loop pointer as a fully functioning alternative controller to interact with pictures, videos and music, and more.
Technically speaking, tech companies could build a fully functioning alternative, but they couldn't determine income-based discounts, which would defeat the purpose of the new law.
"So in terms of a need for a cheap, fast, functioning alternative form of payment, yes - Bitcoin does have a greater opportunity in sub-Saharan Africa".
Central is the concept of an "AIs-Deletions matrix", which captures all possible combinations of gain-of-function alternative inputs and loss-of-function deletions summarizing the results of a systematic epistasis experiment.
To characterize the morphologies induced by the AIs more systematically and to search for new morphologies, we combined the gain-of-function alternative inputs with loss-of-function deletions.
These results demonstrate, for the first time, a functioning alternative MVA pathway.
Since the WOMAC pain scale is inadequate for elders with low cognitive functioning, alternative pain measures are needed.
