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Although allowing for some degree of sub-functionalization of protein function, alternative transcription/splicing does not completely relax the constraints imposed by pleiotropy.
Essential for protein function, alternative splicing appears also to be determinant for the regulation of transcript abundance; it can indeed reduce gene expression by yielding isoforms that are degraded by non-sense mediated decay or other mechanisms [10].
To test whether Abi2 splicing is related to this higher brain function, alternative splicing was studied by brain dissection, which revealed that the relative amount of the inclusion isoform was increased in the frontal cortex compared with other tissues (Figure S3).
Many of the sites involved in a coevolutionary relationship in a bacterial group have been reported to be involved in a GroEL function alternative to protein folding.
As c. 40%% of the sequences generated in the present study lacked significant similarity to genes of known function, alternative computational means were used to identify more sequences, such as identification of ORFs, use of reciprocal analysis and relative coverage in the transcriptome.
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Over time, the name has lost its punny puckishness much as the movement has steadily shifted from a proudly anacharical – even populist – response and rebellion within the GOP to a smoothly functioning alternative to it.
* KODAK Theatre HD Player: Owners of the highly acclaimed KODAK Theatre HD Player can use the Loop pointer as a fully functioning alternative controller to interact with pictures, videos and music, and more.
Technically speaking, tech companies could build a fully functioning alternative, but they couldn't determine income-based discounts, which would defeat the purpose of the new law.
"So in terms of a need for a cheap, fast, functioning alternative form of payment, yes - Bitcoin does have a greater opportunity in sub-Saharan Africa".
Central is the concept of an "AIs-Deletions matrix", which captures all possible combinations of gain-of-function alternative inputs and loss-of-function deletions summarizing the results of a systematic epistasis experiment.
To characterize the morphologies induced by the AIs more systematically and to search for new morphologies, we combined the gain-of-function alternative inputs with loss-of-function deletions.
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