Our observations indicated that in contrast to somatic cells with dually controlled Separase, PGCs have insufficient Securin to fully inhibit Separase and, therefore, their inhibition of Separase is dependent mainly on inhibitory phosphorylation.
These studies implicate Drp1 as a key player in apoptosis, with Drp1 inhibition reported to slow, rather than fully inhibit apoptosis (Frank et al., 2001; Estaquier and Arnoult, 2007).
These observations suggest that non-covalent inhibition of 20S β5 activity alone is not sufficient to fully inhibit the proteasomal degradation of either 4xUb-Luc or IκBα, at least over the time-scale of these cell-based assays.
Importantly, we identify potent BLMH inhibitors that are able to fully inhibit endogenous BLMH activity in intact cells.
Supporting the His57 re-orientation, Zn2+ does not fully inhibit hK5 hydrolysis of tripeptidyl substrates containing a P2 His residue.
However, early clinical data for direct FLT3 inhibitors provided only modest results because of the failure to fully inhibit FLT3.
An altered physical pressure on the open physis can result in a stimulatory or inhibitory effect on growth and extreme forces can even fully inhibit growth.
It was also noted that, lowering the poised potential from −0.25 V to −0.28 V (the fuel standard oxidation potential) did not fully inhibit microbial respiration.
In contrast, use of the more selective aminopyridine CMPD 6o at concentrations that fully inhibit JNK1/2 had a positive effect on cellular proliferation of immortalised WS cells, but no effect on the replicative lifespan of primary WS fibroblasts.
Therefore, it is possible that neurons do not contain enough Smac protein to fully inhibit XIAP.
However, it was also reported that TKIs do not fully inhibit HER2 oncogenic function at conventional doses and concentrations [24].
