Moreover, at these stages, the circadian clock is fully functional, and clock-controlled processes, such as cell cycle timing (Dekens et al., 2003; Laranjeiro et al., 2013) and locomotor activity rhythms (Hurd and Cahill, 2002), become evident.
Significant progress has been made in identifying the core clock genes and the functions of their protein products in the clock mechanism, yet it is clear from other studies, including mutagenesis screens, that additional genes are necessary for a fully functional circadian clock (Takahashi, 2004).
Indeed, fully functional local clocks are necessary for appropriate circadian control of tissue specific physiology in the periphery.
We chose to use cultured third-instar larval brains for live imaging, as larval circadian circuits are numerically simpler yet composed of fully differentiated and functional clock neurons35.
Both toys are fully functional, with one Grandfather Clock currently residing at friend of Buijs' house.
DOI: http://dx.doi.org/10.7554/eLife.02510.028 The hepatic core clock remained fully functional and showed only modest period lengthening of free-running rhythms (on average by 40 min) in Dicer knockout liver explants.
Overall, the core clock appears to be fully functional.
Ms. Tennenbaum's hands are tied and untied by the vagaries of insurance coverage: a young woman who needs radiation treatment but is otherwise fully functional will be discharged with round-the-clock aides because she receives Medicaid.
"He is fully functional".
I wasn't fully functional.
Together, they are fully functional.
