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In contrast, the method presented herein is fully automatic, fully empirical, and focused on scaffolds, a central concept in medicinal chemistry.
To overcome the limited applicability of fully empirical models, a simple though general Darcy model was used to describe flux reduction.
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A challenge to use the pair of transits predicted to occur in 1761 and 1769 to transform astronomy into a fully fledged empirical science by calculating the distance of the earth to the sun.
These models can be estimated through a fully or empirical Bayesian approach, and are implemented in BayesX [ 12].
Some of their apprehensions, voiced with special eloquence by a contemporary Harvard University logician, Willard Van Quine, are based on the claim that relations of synonymy cannot be fully determined by empirical means.
More specifically, the role of design quality has not been fully addressed in empirical studies.
Therefore, because the strength of the improved ground and the suitable length and width of the improved area have not been fully understood, an empirical design has been applied in every case.
The results portrayed are effect estimates from the binary probit model, interpreted as marginal probability effects that arise from the fully specified/fully adjusted empirical model (see Table 2).
The negative correlation of mean genetic distance between MHC IIB alleles and the number of parasite morphotypes could be interpreted in support of the ' divergent allele advantage', which has to our knowledge not yet been fully proven by empirical studies.
However, the genomic model assumes a long, multistep process of macromolecular synthesis; it does not fully account for empirical evidence that the signal response to some hormones is so fast it must be initiated outside the cell via membrane receptors connected to fast-acting molecules.
This is the first report of a semi-empirical fully coupled model which allows one to quantify and investigate the effect of the gas phase and bubble coverage on PEM cell performance up to very high current densities of about 5 A/cm2.
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