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Thus far discrete functional mechanisms have not been fully elucidated for each class of promoter.
Since optimal and appropriate therapy is not fully elucidated for KPC, we assessed adequacy in several manners.
The molecular machinery required for the DIF-1 response in D. discoideum has yet to be fully elucidated; for example, how cells receive the DIF-1 molecule remains unclear.
Many studies have indicated that improvement in clinical response occurs more frequently with moderate-to-high SLIT doses, but the optimal SLIT dose still has not been fully elucidated for most antigens.
Thus, the functional differences and the interplay between types I and III IFNs are likely to lie in the fine detail of this signalling pathway, yet to be fully elucidated for IFNλ, and in the differential distribution of cells that both produce IFNλ and are able to respond to IFNλ through the presence of appropriate receptors.
Although the assignment of the RNAP-binding regions to each strand was achievable using the expression profiles [ 7], it was difficult to assign σ-factors directly to the promoter regions because information on the cis-acting sequence elements, such as the −10 and −35 boxes in the promoter regions, is not yet fully elucidated for each σ-factor.
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Information on substrate flow and regulation through the branch point between flavonol and anthocyanin synthesis is however not fully elucidated, and for tomato the enzymes acting in the branch point have not been extensively characterised.
In addition, it is critical for interpreting clinical data that the biological mechanisms related to changes in [18F] FDG uptake are fully elucidated, a task for which pre-clinical experimentations is particularly well-suited.
Since the molecular background of this disease is still far from fully elucidated, the search for any specific markers (prognostic, therapeutic) of this disease would be of great value and importance.
So far, the furfural and HMF degradation pathways of C. basilensis HMF14 constitute the only fully elucidated metabolic routes for these compounds (Koenig and Andreesen 1990; Koopman et al. 2010b; Trudgill 1969).
Since the molecular background of these diseases, especially endocardiosis, is still far from fully elucidated, the search for any specific markers (prognostic, therapeutic) of this disease would be of great value.
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