Pyrimethamine (an inhibitor of dihydrofolate reductase), atovaquone (an inhibitor of the mitochondrial cytochrome c) and primaquine (putatively a mitochondrial inhibitor), have all been demonstrated to fully inhibit normal hepatic stage parasites in vivo and in vitro [10], [21], [22], [23], [24], [25].
The Ron G. Kermisch '88 Award for implementation of a fully demonstrated physical prototype went to Brella, a personalized weather app that summarizes local weather and suggests clothes to wear.
Robot-mediated neuro-rehabilitation has been proved to be an effective therapeutic approach for upper limb motor recovery after stroke, though its actual potential when compared to other conventional approaches has still to be fully demonstrated.
"The individual has since written to the BBC stating that they would not wish to benefit from a payment that could not be demonstrated to be fully and appropriately authorised," said the NAO.
Two regions of beta G spectrin were expressed in bacteria and demonstrated to contain fully functional binding site(s) for a subset of spectrin-binding sites in brain membranes depleted of peripheral proteins.
Mr Keating, who was the BBC's director of archive content until he left last year to become chief executive of the British Library, told the NAO that they would not wish to benefit from a payment that could not be demonstrated to be fully and appropriately authorised.
Uterine PMNs from susceptible mares have been demonstrated to be fully functional if given an optimal environment.
Moreover, transgenic strains allow the expression of fluorescent fusion proteins, which were demonstrated to be fully functional by genetic complementation tests.
While the link between steroidal efficacy and BBB needs to be fully demonstrated in patients, we believe that the results we present herein are adequate to warrant an in-depth investigation of the BBB-corticosteroid-epilepsy relationship.
