Sentence examples for fully deficient from inspiring English sources

In agreement with previously reported data [6], we found no significant difference in serum Ig concentration between heterozygous and fully deficient AID mice (Figure 1d), presumably due to the high variablity in Ig titers.

Here, we have used in vitro and in vivo analysis of wild type mice and of two Lrp4 mutant mouse strains, one fully deficient (null mutant, Lrp4-/- Lrp4-/- Dietrich, in pretalation) and a functional hypomorph (Lrp4-ECD; [18]) to show that Lrp4 is an osteoblast expressed receptor for Dkk1 and sclerostin and regulates bone growth and bone turnover in vivo.

To determine if EBOV could inefficiently infect these bat cells via an NPC1-independent mechanism, we used CRISPR/Cas9 genome engineering to derive an African straw-colored fruit bat cell line fully deficient in NPC1.

The low resolution of these phenotypes and the apparent phenotypic overlap between mice deficient in a subset of V1Rs and those fully deficient in V1R response suggest that individual V1Rs make combinatorial or additive contributions to broad behavioural patterns, as opposed to each V1R directing a distinct behaviour.

This analysis revealed a similar reduction in CD4+ DCs to that seen in fully deficient mice, establishing an intrinsic role for EBI2 in these cells and showing that the phenotype was not increased when the mutant cells had to compete with wild-type cells.

However, a decrease in the total number of calbindin-labeled cells was observed within the cortices of triple Robo mutant animals (n = 2) relative to an animal which was heterozygote for both Robo1 and Robo2 receptors and fully deficient for the Robo3 receptor (Robo1+/−Robo2+/−Robo3−/−).

However, since MVA is fully replication deficient, pre-existing immunity is unlikely to affect the immunogenicity of these vector vaccines to a great extent and did not prevent the induction of humoral responses to the expressed protein [35] [37].

Given that we have now shown that E. coli can be converted into a state in which the cell wall precursor pathway can be deleted and cells become completely resistant to β-lactam antibiotics, we suggest that in future the term L-form be restricted to fully wall deficient cells.

We note that our knockdown lines are not fully FLN-deficient and residual FLNa or FLNb along with up-regulated FLNc may provide sufficient crosslinking activity so we do not exclude a role for FLNs in regulation of the actin cytoskeleton.

found that mice with ovarian tumors partially or fully C3-deficient had a significantly different tumor immune infiltrate compared to controls.

Our estimated deletion frequency for dinucleotides in LCL1261 cells is ≤ 10−4, which is lower than the deletion frequency observed in the fully MMR-deficient HCT116 cell line (Table 2).