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There are a number of precedents for the transcriptional regulation of a select subset of p53 target genes, including those inducing either apoptosis or cell cycle arrest and senescence.45, 46, 47 In this study, the preferential repression of p21WAF1 and miR-34a, but not BAX and PUMA, by Δ133p53 may not fully be explained by the FL-p53 binding to their promoter regions in the ChIP-qPCR assay.
Interestingly, this risk seems to be restricted to females and cannot fully be explained by the effect of the APOE alleles on cholesterol levels.
This demonstrates that associations between these properties and HI cannot fully be explained by the over-representation of gene essentiality among HI genes.
The high prevalence can also not fully be explained by the inclusion of RAD among the diagnoses assessed, because RAD contributed to only 6.1% of the total prevalence in the study sample.
Only 2% of all samples had p,p′-DDT concentrations above LOD; however, this could not fully be explained by the instrument performance as previous studies from the same areas have reported considerably higher concentrations of p,p′-DDT than the LOD in the current study.
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The fact that the increase in incidence has been predominately in males suggests that the rising trends in these cancers cannot fully be explained by changing classifications of the diseases or improvements in diagnosis [ 7, 8].
This indicates that the effect of gene function cannot fully be explained by structural characteristics of transcripts included in the regression.
Further, low fructose concentrations at the fully ripe stage may be explained by the presence of invertase enzyme which increases in activity during ripening (Ramsey and Wang 1962).
Next, we have fully examined how the focal mechanism data are explained by the estimated stress.
We suggest that the mechanisms are coupled to, and can be explained fully by, the DNA sequence-dependent regulation of recombination hotspots.
These effects are considered not to be explained fully by the lowering effect of blood glucose [ 20].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com