The MIP protein of Burkholderia pseudomallei is important for replication and full virulence, rendering it a potential target for antimicrobial substances.
PQS is also required for full virulence towards plants (Cao et al., 2001), nematodes (Gallagher et al., 2002) and mice (Cao et al., 2001; Lau et al., 2004).
oryzicola (Xoc), the causal agent of bacterial streak disease on rice, is indispensable for full virulence and biofilm formation by Xoc (Qian et al. 2013).
The current concept postulates that the full virulence factor arsenal is required to overcome the human immune defense as successfully as S. pneumoniae does (Mitchell 2011; Doern and Burnham 2010; Whatmore et al. 2000).
Further, IQS has been shown to contribute to the full virulence of P. aeruginosa in four different animal host models (mouse, zebrafish, fruitfly and nematode), highlighting the important roles of this new QS system in modulation of bacterial pathogenesis.
A recombinant P. aeruginosa PAO1ΔpscD::exlBA strain, deficient for T3SS but engineered to express ExlA, gained lytic capacity on endothelial cells and full virulence in mice, demonstrating that ExlA is necessary and sufficient for pathogenicity.
Yersinia Pestis outer proteins, plasminogen activator protease and Yop secretion protein F are necessary for the full virulence of Yesinia pestis and have been proposed as potential protective antigens for vaccines against plague.
In the shrimp pathogen Vibrio nigripulchritudo, two plasmids are important for full virulence [22], [23].
Thus, it is unlikely that xaxAB hemolysin is required for the full virulence of X. nematophila.
These data illustrate the necessity for an intact RopB for full virulence in vivo.
Both agr and sarA are essential for full virulence during invasive S. aureus disease [47], [48].
