Exact(32)
One full transporter (Reut_B5799-5801) and one binding protein (Reut_C6311) may be involved in aromatic compound transport.
Of these, ABCB5.ts is a putative full transporter expressed specifically in the human testis.
This suggests that ABCB5 has evolved as a full transporter throughout its evolutionary history.
The ABCB5.ts (full transporter) has 23 non-synonymous cSNPs, which map to different functional regions of the putative transporter.
The ABCB5 full transporter gene is located on chromosome 7p21, spans 28 exons and 141.8kb of genomic DNA.
The ABCB5 full transporter (ABCB5.ts) is expressed in human testis and its functional significance is presently unknown.
Similar(28)
The ABCA subfamily, of which the ABCA12 gene is a member, comprises 12 full transporters and one pseudogene (ABCA11) that are essential for lipid transport and secretion.
The ABCB full transporters originated from a single gene that is present in non-vertebrates and goes back as far as Drosophila, C. elegans, and yeast.
A phylogenetic analysis indicates that ABCB5 is most closely related to the other full transporters, ABCB1, ABCB4, and ABCB11 (fig. 5).
In the full length protein HMMTOP predicted the presence of the conventional 12 TMs with the 2 NBDs, which represents the accepted model for most full transporters (fig. 1A).
In human, all ABCA transporters are full transporters [ 2].
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