Sentence examples for full transformation of from inspiring English sources

In conclusion, we demonstrate that the two MAP kinase kinase isoforms MEK1 and MEK2 have similar transforming properties and that activation of either isoform is sufficient for full transformation of intestinal epithelial cells up to the metastatic stage.

It was here Gaye conceived his 1971 spiritual masterwork What's Going On, a full transformation of his sound.

Meg Whitman, H.P.'s chief executive, said a full transformation of H.P. might take as long as five years.

The president has much to do to convince the world that he is committed to the full transformation of his country.

Full transformation of infected B-cells is achieved by the contribution of poorly defined additional co-factors, including microenvironmental stimuli, genetic and epigenetic alterations.

This "ergonomic barrier" inherent in the present design of laparoscopic instruments significantly inhibits the full transformation of expert surgeons' skill into a proportional increase in their surgical performance.

Such models rely on the serial transfection of human primary cells with defined genetic factors that promote immortalization, and ultimately full transformation, to cell types capable of initiating cancers in animal models.

These observations provide evidence that AREG-mediated activation of endogenous EGFR is required for full transformation downstream of YAP.

We never observed a full transformation resulting in the production of sperm or egg in mutants of the opposite sex.

To avoid full transformation and minimize the risk of abnormal self-antigen expression, we have instead used a molecular clone of SV40, rendered unable to replicate through an internal deletion in the large T-antigen, which immortalized primary feline fibroblasts as efficiently as wild-type SV40 (data not shown).

Importantly, these analyses provide a strong rationale for further definition of various mammary epithelial subtypes and expansion of immortalization and full transformation strategies to derive models that may faithfully reproduce the histological and molecular diversity encountered in human breast cancers.