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This showed that the brains of the premature pups had fewer glutamate-producing pyramidal neurons than those of the full term pups.
Antibody staining further revealed that the full term pups had higher levels of three proteins whose expression is induced by conditions of oxygen deprivation, reflecting the fact that they had just been born.
This is exactly what the researchers found – they treated some of the premature pups with a drug called dimethyloxallyl glycine (DMOG), which activates the genes that are normally expressed under conditions of oxygen deprivation, and found that this increased the production of neurons, so that their numbers were comparable to those seen in the brains of the full term pups.
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However, only 11 of those embryos or 3% grew into full-term pups, compared with 62% for eggs taken from adult mice and fertilized in vitro.
The immature fetal small intestine has an excessive response to mucosal injury compared with the small intestines of full-term pups.
They examined the brains of rabbit pups born at 29 weeks (or three days premature), and compared them to those of newborn pups that reached full term.
The observation that rabbit pups that reach full term express higher levels of genes that are expressed by oxygen deprivation suggests that the conditions in the womb promote the production of new neurons, and that premature birth suppresses this process by exposing the foetus to oxygen earlier than normal.
The pups were divided into three groups: -group 1 (control group, n = 10): the neonatal rats were obtained after spontaneous vaginally delivery at full term and were mother-fed; -groups 2 and 3 (experimental groups): the pups were obtained by preterm delivery by caesarean section at day 21 of pregnancy.
Nobody served a full term.
"That's pretty much full term".
And will you run full term?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com