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Full scale trials with the vessel constructed according to the chosen design later revealed a satisfactory performance in all critical aspects.
In general there exists a significant number of knowledge gaps in the field of RT because the studies that have been conducted to date have almost exclusively occurred in pilot plant or full scale trials; this approach greatly limits the amount of process optimization that can be done in a given trial.
Power calculations were reported in four of the 19 "full scale" trials 20, 21, 23, 45 and in one of these the participants included prostate cancer and breast cancer patients in the calculation 20.
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After a successful full scale trial to determine the efficacy of aerated wetlands, the entire treatment system was upgraded and optimized in 2010.
In all, the present study suggests that the next step is to include children with cognitive disabilities into a full scale trial.
We submitted a protocol for a full scale trial to the MRC in early 1993.
However, several issues need to be addressed before a full scale trial is undertaken.
The randomised controlled component allows testing of procedures, design, etc in preparation for a full scale trial.
Furthermore, the results using the factorial design will inform the optimal intervention to be used in the full scale trial.
These data can be used to project required sample sizes for a full scale trial, as follows.
The pilot trial was designed to provide benchmarks from which to project the sample size required for a full scale trial.
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