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In addition, not all other patients are full responders.
A subgroup of 72 full responders elected to taper and discontinue medication treatment.
Overall quality of life was lower for short-questionnaire responders than for full responders, but the difference was not statistically significant (Δ=7.62, P=0.1209).
Some authors, however, did not observe statistically significant differences between these outcomes in full responders and non-immunologic responders [ 26, 27].
At 5-year follow-up, mean age of survivors who returned a full questionnaire (full responders) was 72 years (standard deviation: 9 years).
However, despite a significant percentage of full responders in trials, there exist subpopulations of patients that are only partial responders or appear desmopressin resistant [ 16].
Similar(46)
The number and proportion of patients was summarised by responder status (non-responder, partial responder, responder and full responder) for the two different treatment sequences.
Five patients were classified as partial responders (i.e., a minimal symptom reduction 25%) and one patient as a full responder (i.e., a minimal symptom reduction of 35%).
The probability of having an amelioration (i.e. reduction in bedwetting; defined as partial responder, responder or full responder) during period 1 and 2 was analysed using a repeated logistic regression model with terms for sequence, age, treatment, dose group, period and a random factor for subject.
In the TPJ condition, results were similar; out of N = 9 patients with DPD, N = 4 would meet criteria for being a partial responder, and N = 1 would be classed as a full responder i.e. showed a 50% reduction in CDS scores post rTMS, according to criteria [39].
Although there seem to be some full-responders, the average reduction in migraine days compared to placebo is only in the excess of 1 day per month when administering any CGRP antibody [4].
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