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This extraordinary temperature dependence seems to be due to the hindrance on full reorientation of the dangling chains by the PCL spacer crystals formed at the air interface.
On average, we achieve sequence recoveries in the binding site of 59% when the ligand is allowed limited reorientation, and 48% when the ligand is allowed full reorientation.
The E276 in this structure does not appear to have undergone full reorientation, which could contribute to reduced oseltamivir binding found in the Indonesian clade 2 isolates here.
In light of the findings in the present study it would be reasonable to ask whether return to work presupposes a full reorientation of all parts of a person's life, as well as whether this is a privilege reserved for generous welfare systems, as in Norway.
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A recently developed constitutive law, accounting for full martensite reorientation as well as phase transformation, was implemented into the commercial finite element code ABAQUS.
"If he doesn't show that Russians get something out of this new full-fledged reorientation toward the West, he could easily back away toward what he did before -- back toward the tactician, finding the medium on every issue".
Moreover, binding of ssDNA substrate is found to cause dramatic reorientation and full coupling of inter-domain motion.
The theory is physically based, and in particular, is based on a kinematical framework fixed on the fabric laminates; full accounting of laminate reorientation and anisotropic response is thus achieved.
This result can be interpreted as: 1) they are sufficient to trigger centrosome reorientation as the WT full-length Scribble; or 2) they function as dominant-negative constructs, because PDZ domains of Scribble is known to be important for its polarity function.
When simulating the redesign of a protein binding site, sequence recovery among residues that contribute most to binding was 52% when slight ligand reorientation was allowed, and 27% when full ligand reorientation was allowed.
It is shown that the ability of the model to consider the reorientation of the transformation strain tensor results in full recovery of transformation strain upon unloading, and a uniform distribution of stress in the transformed areas in spite of the localization of transformation.
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