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The seasonal patterns in Figure 3 assumed an equal and full range of exposure in the population.
A second unspoken assumption of seasonal analyses to date is that the entire population experiences the full range of exposure.
This dose-response plot preserves the full range of exposure levels and their cognate responses, avoiding the pitfalls of collapsing exposure categories.
Nonetheless, the results of the two cohort studies, one in African Americans and Dominicans and the other in Caucasians, are generally consistent, both across the full range of exposure and restricting to the common, lower range.
Indeed, recent studies of the long-term sequelae of early lead exposure would suggest follow-up to adolescence and young adulthood is necessary to reveal the full range of exposure related morbidities.
The intent here is to describe the mortality experience of workers exposed to Libby amphibole fibers (tremolite asbestos, winchite, richterite) over the full range of exposure and employment duration.
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"Central monitoring doesn't pick up the full range of exposures for many compounds, and personal exposures are higher still," said Dr. John D. Spengler, a professor of environmental health and human habitation at the Harvard School of Public Health, which is analyzing part of the backpack results.
However, these studies did not assess the full range of exposures, possibly leading to an under-estimation of the importance of unexpected death and witnessing.
The significant lack of fit when the high-dose group was included suggested that the recommended models do not accurately reflect responses over the full range of exposures studied.
Levels of individual exposures to PCBs and related compounds were characterized by analyses of milk collected from the same women 3 5 days after parturition; 211 women were then selected to represent the full range of exposures, with oversampling of subjects with low and high exposure levels.
Representativeness matters considerably in attempts to generalize prevalence estimates of an exposure or a disease, but it is much less of an issue in the interpretation of measures of association in a cohort study, provided the full range of exposures is observed in the population.
More suggestions(15)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com