Exact(12)
Dr. Shapiro added that he would feel more comfortable in making a judgment if he saw a full pathology report.
A full pathology examination of offspring was performed at the end of the 9-month postnatal period.
The pathology findings from all studies were subjected to a full pathology peer review.
Of the 840 cases diagnosed, full pathology and treatment information was available for 586 cases.
Additional information was accessed from electronic medical records (EMR) that archives all clinic letters with access to full pathology and radiology reports.
Although these studies showed that immunisation with Aβ was successful in animals, the models used, however, did not reflect the full pathology of AD (that is, they lacked NFTs or substantial neurodegeneration despite Aβ deposition).
Similar(48)
Specialty board examinations that used to be full of pathology pictures are now full of radiologic images.
Accumulation was apparent four years post graft, but not until 10-14 years post graft was full Lewy pathology evident [ 21].
Simply abandoning the term "model" because it is highly unlikely that it can mimic the full blown pathology or syndrome, as suggested by O'Neil and Moore [ 31], will not help to improve animal experimentation.
Complex translational problems that preclude simple animal model extrapolation in CNS R&D include (i) fundamental differences in neurotransmitter circuitry between rodents and humans, (ii) the incomplete representation of the full human pathology, (iii) the absence of important functional genotypes in animal models, and (iv) the existence of unique pharmacologically active human metabolites.
They represent full-fledged pathology that has devastating consequences for the LGBT community.
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