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In order to allow tracking, the full marker must always be visible.
The full marker set can be downloaded as a text file at http://www.genenetwork.org/dbdoc/BXDGeno.html.org/dbdoc/BXDGeno.html
It also appears that the discordant SNPs had lower performance than the full marker set; however, the averages between the two sets were not markedly different (Table 3).
The model described here assumes a full marker data set, but it can be readily modified to consider missing marker data based on a hidden Markov model as advocated by Jiang and Zeng [48].
Theses adjustments were repeated with PC scores and the Northwest African ancestry estimates obtained from the full marker set and subsets of the markers ranking higher for ancestry informativeness.
Adjusting for STRUCTURE estimates, based on the full marker set or any of the subsets of markers ranking higher for different measures of ancestry informativeness, barely decreased the number of significant tests (Table 3), while significance levels dropped considerably (Figure S2).
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Figure 1 Comparison between MM (full markers) and hybrid-FE (empty markers) natural frequencies for (8,0) SLGSs with different widths.
Two simulations were run for each strategy, one with the proper number of idle cycles (curves with full markers), and the other without idle cycles and referred to as full pipeline mode (curves with empty markers).
a Full markers list is provided in Additional file 6.
Simulated traits were constructed by first generating additive genetic values from the multivariate normal distribution, with variance equal to the full-marker relationship matrix (hence, σ = 1).
The shrinkage intensities in Figure 2 were based on minimizing the expected MSE, as determined from a reduced marker set. Figure 3 (using m = 384 markers) shows that this approach did in fact minimize the actual MSE between the full-marker relationship matrix and that based on the reduced marker set (see Figure S2 for 2+6-row barley).
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