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However, the effect of this mutation on the full-length protein localisation was not investigated.
By linking the deconvolution results of the k-sets pooling design to the KeyMaps anchoring procedure, the performance of the pooling design was enhanced above its intrinsic capacity to resolve the positive QPPs, and full efficiency of marker localisation in the QPPs was retained for the high copy number AFLP markers.
Streptavidin-Irgm1 αK complexes showed striking co-localisation with full length Irgm1 at both Golgi apparatus and lysosomes.
The implication of this observation is that Golgi and lysosomal localisation of full-length Irgm1 depends on the amphipathicity of the αK helix.
The Irgm1 αK helix was required not only for targeting EGFP to Golgi and lysosomes, but also for the correct localisation of full-length protein ([20] and this report).
Localisation of full-length APC is also very prominent in basal most regions, where it is present in clusters, dependent on intact microtubules (Rosin-Arbesfeld et al, 2001; Mogensen et al, 2002).
On the dorsal STIR- and T1W SE-images the extent and the localisation of the full mass compared to the surrounding structures is visible.
Thus, a disrupted BBB is not enough to account for the full range of brain tumour localisation we observed with Angiopep-2 conjugates, but instead required specific targeting and/or retention mediated by Angiopep-2.
Three different chimeric constructs were prepared to verify the localisation of the full length protein (pG2HPLF1-YFP) and the role of the first eleven amino acids at its N-terminus in the final targeting of HPLF (pG2HPLF2-YFP and pG2HPLF3-YFP).
The FAPP2 PH domain belongs to a family of PH domains that share high sequence homology and a preferential interaction with PtdIns4 P. Indeed, FAPP2-PH, as well as the PH domain of FAPP1, OSBP1, ORP9, and CERT, drives the localisation of the full length-protein(s) to the TGN by recognizing and binding PtdIns4 P, which is enriched on the cytoplasmic membrane leaflet of this organelle [13].
