Exact(1)
Interventions Randomised assignment to trophic or full feeding for up to six days; thereafter, all patients still receiving mechanical ventilation received full feeding.
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Matthew: They don't have full feeds for everything.
With the exception of the SF-36 mental health measures that favoured trophic feeding, there were no significant differences between trophic and full feeding groups for all other secondary outcome measures, including functional activities, fatigue, psychological symptoms, cognition, and employment status (table 3, fig 3).
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The largest of these trials, the EDEN study randomized patients (n = 1000) with acute lung injury to receive either trophic feeding at 20 kcal/h (which is about 7 cal/kg/day) or full feeding at 25 30 kcal/kg/day for the first 6 days (the average protein dose received in each group was not reported!) [65].
The largest of these trials, the EDEN study randomized patients (n = 1000) with acute lung injury to receive either trophic feeding at 20 kcal/h (which is about 7 cal/kg/day) or full feeding at 25 30 kcal/kg/day for the first 6 days (the average protein dose received in each group was not reported!) [ 65].
There was no significant difference in the mean age and sex adjusted SF-36 physical function domain score (55 (SD 33) v 55 (SD 31) between the initial trophic and full feeding groups; mean difference adjusted for age and sex 2 (95% confidence interval −4 to 7, P=0.54).
Four randomized controlled trials have been performed comparing permissive underfeeding to full feeding or standard feeding to 'PepUp' feeding [65 68].
Four randomized controlled trials have been performed comparing permissive underfeeding to full feeding or standard feeding to 'PepUp' feeding [ 65– 65].
1 2 3 4 5 6 7 The Acute Respiratory Distress Syndrome Clinical Trials Network of the National Heart , Lung and Blood Institutepublished a large, multicentre randomised open label trial of initial trophic compared with full enteral feeding for up to six days in patients with acute lung injury (the "EDEN trial").
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