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The resulting HRs and corresponding 95 % CIs were not significantly different to those for the full dosing groups [ 25].
Thus, these results suggest in vivo efficacy is related to an extended drug exposure over the full dosing interval in addition to in vitro inhibition potency (EC50).
Among 1065 instances of EVE dose interruptions/reductions, 463 (44%) resolved with resumption of full dosing; 352 of these events (76%) resolved within 2 weeks.
Will human antichimeric antibody (HACA) development be avoided by full dosing and by combination with cytotoxic agents, in parallel with the experience with infliximab [ 28]?
Additionally, all currently recommended treatments require frequent and prolonged antibiotic administration which makes owner non-compliance with the full dosing regimen a concern [ 4].
Treatment of gout in patients with CKD is complicated because full dosing of allopurinol, the uric acid-reducing medicine, requires adequate renal function to clear oxypurinol, its active metabolite [ 9].
Similar(54)
Now I'm back on a full dose".
People in anaphylaxis need a full dose every time.
"But it wasn't the full dose, and so it didn't do any good.
A full dose of fertilizer can be given in a few weeks.
Eventually my doctor changed the drug, but even then I wouldn't take the full dose.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com