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They compared prednisone followed by full doses of 6-MP, methotrexate, and a new drug, cyclophosphamide (CTX), with prednisone followed by half doses of 6-MP, methotrexate, and CTX.
So MOMP became MOPP: two full doses of nitrogen mustard and vincristine on the first and the eighth days, and daily doses of procarbazine and prednisone for fourteen days, followed by two weeks of rest.
This held true even in a subset who got full doses of both drugs.
Patients who received full doses of adjuvant chemotherapy were eligible.
The combination diet contained full doses of both compounds.
60% of patients were able to tolerate full doses of treatment without significant toxicity.
Full doses of both drugs were given in cases with grade 0 1 toxicity.
Forty-two patients (91%) had full doses of drugs for at least four cycles.
Full doses of carboplatin and docetaxel were administered in 96 and 94% of cycles, respectively.
Twenty four (57.2%) patients received full doses of all the drugs throughout the study.
Full doses of the anticancer drug were given if granulocyte count was >1500 microL and platelet count was >100000 microL.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com