In vitro cytotoxicity studies of the complexes using MTT assay exhibited a significant enhancement in the cytotoxic capability.
In particular, compounds 8 and 9 have similar cytotoxic capability as cisplatin does.
As shown in Figure 5, f-HNT-ASODN complexes displayed a significant enhancement in the cytotoxic capability compared with that of the ASODNs alone.
The PMN dysfunction - characterized by an increase in cytotoxic capability and a decrease in microbicidity - showed a parallel course to the heparan sulfate plasma levels.
Moreover, CD4+CD28null T cells have cytotoxic capability, can effectively kill endothelial cells in vitro, and may contribute to endothelial cell injury in coronary plaque [ 10].
Its inhibition by a tumor cell product was implicated in the progression of advanced squamous cell tumors [ 32] suggesting its cytotoxic capability against target cells.
This time was shown to correlate with maximum cytotoxic capability of the CIK cells, but it is clearly sub-optimal for trafficking.
It was seen that although CKR cell-surface levels peaked at day 14, the cytotoxic capability of the cells did not reach maximum levels until day 28.
It is likely that T cells have not acquired the full cytotoxic effector functions at this stage of the activation.
Our results indicate that introduction of a functional TCR into a hematopoietic progenitor cell can lead to the efficient generation of antigen-specific T cells with cytotoxic capabilities.
