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A standardized full colposcopic evaluation including the vulvar, vaginal, and perianal regions was performed by trained gynecologists.
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Specifically, we detected 19 cases of CIN2+ in our study, representing an overall prevalence among the population of women with full colposcopic and histologic evaluation of 2.8% (CIN2/3 = 2.2%; cancer = 0.6%).
We also evaluated the impact of having a colposcopic evaluation during the enrolment period or as the result of the six month follow-up visit for 492 women with low grade squamous intraepithelial lesions or cervical intraepithelial neoplasia grade I; 11 (2.2%) women seen at the six month follow-up were censored for cervical abnormalities and excluded from this analysis.
Colposcopic evaluation with directed biopsies should be continued.
A previous phase 1 trial included colposcopic evaluation in 36 healthy, sexually abstinent,18 45 year old women in Australia and demonstrated safety and tolerance of 0.5% to 3% w/w SPL7013 gel when administered once daily for seven consecutive days [10].
All patients enrolled in the study were first subjected to colposcopic evaluation.
All the women underwent a rigorous colposcopic evaluation that included using a microbiopsy protocol.
All the women underwent a rigorous colposcopic evaluation that included using a microbiopsy protocol as previously described [ 13, 15].
A detailed gynecologic and colposcopic evaluation was carried out if there was any abnormal cervical cytological finding.
18 20 VIA-positive women are referred to BSMMU and government medical college hospitals for colposcopic evaluation and management.
We recorded indication for and date of referral, age at referral and final diagnosis following colposcopic evaluation and/or treatment as appropriate.
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