Sentence examples for full abrogation from inspiring English sources
Full abrogation can only be achieved with mutations of both Y602 and Y779.
In the experimental design it is also important to consider alternatively spliced transcripts and additional transcriptional start sites to ensure full abrogation of lncRNA expression.
Understanding the general PP2Ac/IKKβ cross talk at the IKK complex, the mode of interference of UVB with PP2Ac activity and the chronology of events leading to full abrogation of the negative feedback loop is of high importance under therapeutic aspects.
The abrogation of full-length YB-1 transcriptional activity was determined with increasing concentrations of CTF expression plasmid.
Transfection of MAD2B deletion constructs with full-length RAN, however, resulted in a complete abrogation of yeast growth and β-galactosidase activity (Fig. 1) indicating that full length MAD2B is required for the interaction with RAN.
Pretreatment of ShhMSCs with these inhibitors abrogated PKM with concurrent abrogation of iNOS and netrin-1.
Treatment of established tumors with DAC resulted in a significant abrogation of tumor growth, causing almost full stasis of growth over the treatment period.
A viable hypothesis for atrophy-independent muscle weakness in aging, therefore, involves substantial abrogation of SOCE, a process vital to the full functionality of E-C coupling.
The goal of any therapeutic intervention is abrogation of pathogenic reactivity to autoantigens, while preserving full capacity to mount a normal immune response against foreign pathogens, with preservation/restoration of B-cell mass and function.
Exposure of cultured cancer cells to UCN-01 (250–1000 n M) resulted in complete abrogation of phosphorylation at Ser473 and Thr308 residues of Akt, both of which are essential for full activation of Akt kinase activity (Amornphimoltham et al, 2004; Kondapaka et al, 2004).
In its petition, the ECI called for the abrogation of Directive 2010/63/EU, which is an EU ruling that states Europe's final goal as "a full phasing out of animal testing," all the while acknowledging that, "animal use is still necessary on the way to reaching this goal".
