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Let (M>0) be a constant fulfilling assumption (H3).
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The HR was checked for consistency over time, fulfilling assumptions of the Cox model.
To fulfill Assumption 1, we assume a linear relation between ρ Crowd and ρ User.
Independent sample t-test was used to compare means between groups for domains that fulfill assumption.
The most traditional way is based on the usually fulfilled assumption that the effective population size is large enough so that the probability of coalescence is small and hence that the probability that two or more coalescences occur at the same generation is low enough so that it can be neglected (e.g. Nordborg, 2007).
This specification fulfills Assumptions 1-3 laid out above.
Data that did not fulfill assumptions were normalized by the arcsine transformation.
In order to fulfill assumptions of homogeneity of variance and normality, detection errors were log-transformed before ANOVA was calculated (Ferguson 1976).
If data did not fulfill assumptions for repeated-measures analysis of variance despite logarithmical transformation, they were analyzed using multivariate repeated-measurements analysis of variance as reported previously [ 14, 18].
In survival analysis cox proportion hazard ratio (Cox regression) was determined for mortality in DHF/DSS and severe hepatitis after fulfilling the assumption of proportional hazard ratio.
All gentamicin products fitted Hill's model, which described their dose-effect relationships with an excellent fit, generating multicollinearity-free, highly significant PD parameters, and a nonlinear regression fulfilling the assumptions of normality, constant variance and independence (Table 3).
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