The completeness property of this method guarantees that calculated treatment plans fulfill the dose constraints given by the oncologist.
In order to fulfill these dose constraints for OARs, tumors with insufficient response after EBRT and required 50 Gy of EBRT without CS generally could only afford two times of brachytherapy sessions while tumors with sufficient response and started CS only after 20 Gy of EBRT could undergo four or even five times of brachytherapy sessions.
At the time of transfer, about two-thirds of the patients adding a morning injection fulfilled the formal dose transfer guidelines, the other one-third were changed through investigator discretion.
Thus, not only are our findings applicable to clinical practice and biologically plausible, but they also fulfill the dose-effect criterion for causality.
The SUCCESS trial partially fulfilled our dosage objective, but one half of the celecoxib patients received double the 200-mg daily dose recommended for OA patients.
Selected efficacy analyses will be repeated in the per-protocol (PP) population (i.e., subset of the mITT1 population meeting the following criteria: all eligibility criteria fulfilled, at least one dose of allocated treatment administered, and RAS wild-type tumor confirmed after central assessment).
In agreement with the Annex XIII of the REACH regulation the category for reproduction toxicity and specific organ toxicity after repeated dose fulfill the toxicity criteria.
However, it was considered a deviation as the disease was still active (that is, dose escalation criteria fulfilled); stopping all disease-modifying anti-rheumatic drugs (DMARDs) regardless of patient's disease activity or toxicity status were considered deviation.
Hands-on and remote handling recycling were assumed to be feasible if contact dose rate limits were fulfilled.
In FEG, the pertussis component of the combined diphtheria, tetanus, pertussis vaccine consisted of alum-adsorbed B. pertussis (30 40 × 109 bacteria/ml), equivalent to at least 4 international potency units per 0.5 ml dose [ 20, 51], fulfilled international potency requirements of at least 4 IPU issued by the World Health Organization in 1964 [ 52].
