Exact(1)
Ideally, the targeted inactivation of single miRNAs that fulfil prospective functions in circadian regulation would allow for more straightforward investigations.
Similar(58)
Ideally, reliable prognostic marker studies should fulfil the following methodological requirements: (1) prospective or longitudinal design; (2) long-term followup; (3) adequate marker and outcome measurement; (4) clinical significance of the marker (i.e., good correlation and consistency with relevant clinical outcomes); and (5) reproducibility [ 131].
For inclusion, studies had to fulfil the following criteria: have a prospective cohort design; report relative risks or hazard ratios and their corresponding 95% CIs (or data to calculate them) of cancer relating to every category of coffee intake; and provide the frequency of coffee consumption.
This on the one hand supports again the goodness of the ranking, confirming that the top-scored genes are actually promising candidates for association with NSHL, on the other hand fulfils our initial requirement to suggest new prospective insights in NSHL.
These designs are methodologically stronger options than uncontrolled prospective observational studies, 27 and could fulfil the role of a definitive evaluation when a randomised controlled trial is infeasible (box 3 shows an example).
In agreement with our other recent reports [32], [33], to be eligible, both patients and controls had to be white and of Italian descent for at least 2 generations, have no relatives among other prospective participants, have given written informed consent, and fulfil predefined group-specific inclusion and exclusion criteria.
After excluding duplicates and studies that did not fulfil our inclusion criteria, 36 references referring to 8 RCTs, 8 prospective cohort studies and 19 case control studies were included.
Sublingual capnometry fulfils none of the criteria required for a health technology to be recommended for widespread use before there are prospective, controlled clinical data to support it.
They help fulfil human needs.
Not all will fulfil it.
They fulfil a different purpose.
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