Doyle [ 38] proposed that members of the cytosolic GS gene family in plants have also evolved by duplication of a single, ancestral cytosolic GS gene and the evolution of separate gene copies to fulfil different metabolic cell requirements.
In particular we show that Treg cells fulfil this role not only during the induction phase but also during the effector phase of the autoimmune response.
In eukaryotic cells, actins fulfil a plethora of different functions, ranging from cell shape and transport to force generation in muscle and in cytokinesis.
Although the mammary primordium should in theory be predicted to be enriched for stem cells, previous functional analysis suggests that only a very small fraction of the primordial epithelial cells can fulfil the standard definition currently used to assay for mammary stem cell function, that is, the repopulating capacity in the cleared postnatal fat pad [ 4].
Therapies to enhance remyelination aim to either stimulate remyelination by endogenous oligodendroglial cells, or aim to add exogenous cells to fulfil this role.
Cancer-causing genes have been classified into three distinct groups: proto-oncogenes, tumour-suppressor genes, and stability genes, according to the biological roles they fulfil in a normal cell and hence, the aberrant process they effect in an oncogenic state[ 2].
Whole-cell biosensors fulfil most of the technical requirements of analytical chemistry such as high specificity, sensitivity and reproducibility, also required by the official methods of environmental analysis (86/278/CEE).
In the present study, we have shown that human umbilical vein endothelial cells (HUVEC) fulfil these criteria.
It therefore remains formally possible that only the subset of breast cancer stem cells that fulfil these criteria is identified in these studies.
To fulfil these roles, stem cells must survive and persist within tissues and also be able to generate specialized, differentiated progeny as required.
