These roadways have typically been frustrating to all manner of wireless communication, posing a problem for everything from AM radio to modern GPS navigation.
Initial attempts to detect Nek8 activity in this manner proved frustrating with similar levels of weak activity being detected with both the wild-type and catalytically inactive Nek8 proteins.
Wenger was clearly frustrated by the manner in which Walcott, Iwobi and, most surprisingly, Özil did not show a great deal of poise when Arsenal were in encouraging positions.
Before the Tottenham defeat, Chelsea had not conceded more than three goals in a Premier League game under Mourinho, who admitted he was frustrated by the manner of his side's second loss in eight league matches.
In my experience, North Koreans are frequently frustrated by the manner in which the media demands that they give testimony.
The use of interprofessional arenas varied broadly from promoting collaboration and learning, to maintaining entrenched workflows (status quo), and finally to discourage collaboration in a manner perceived as frustrating.
Speaking for myself, it's immensely frustrating to hold liberal views on all manner of topics, but still be derided for not subscribing to a specific, wholly negative view of Israel.
"I think the manner in which she has engaged has been frustrating to people," said one of Mr. Giuliani's senior campaign officials.
