4, 5 Until recently, MSA had been defined as a nongenetic disorder, but then several multiplex families with the disease were described, triggering extensive fruitful searches for susceptibility genes in case control association studies.
Without a solid knowledge foundation, pupils won't be able to conduct a quick and fruitful Google search anyway.
Augmenting the therapeutic efficacy of drugs may prove more fruitful than searching for the new ones.
When applying looser criteria, 5p13, 9q33, and 16p13 appear to be the most fruitful loci to search for pleiotropic genes.
The multivariate endophenotype approach has already proved useful in various other domains of endophenotypic research [ 13, 71, 97] and will most likely prove fruitful in the search for common etiological factors for ADHD + ASD.
Based on our previous experiences, we therefore concluded that further assessment of this panel of residues was unlikely to be fruitful in the search for a TAK-779 binding site and was not a good use of resources.
As yet, this linkage signal and those on 5p13 [ 8, 49, 53, 67, 99] and 9q33 [ 8, 77, 84] may appear to be the most fruitful loci to search for pleiotropic genes, since both of these loci are supported by at least two independent studies of autism (although not necessarily genome wide significant), and at least one study of ADHD.
Given the number of recurrent chromosomal breaks observed in breast cancer (http://cgap.nci.nih.gov/Chromosomes/RecurrentAberrations), this line of research might become more fruitful than the search for deletions through loss of heterozygosity data, which has been rather disappointing (Devilee et al, 2001).
It is also drawing on a fruitful category of Web search — vertical search engines that offer results on specific topics.
But semantic analysis is just one of many directions that Google's teams are exploring, and not necessarily the most fruitful in producing daily search improvements.
