The result, said a colleague, Dr. E. Rolland Dickson, a professor emeritus of medicine at Mayo, was a fruitful re-examination of medical education and an end to "a certain laxity in some physicians once they were out of medical school and finished with graduate training".
These multiple sources of variability are already known, but the Key Events approach helps to pinpoint the specific steps in the overall pathway where these pathogen factors may exert their influence and where a more comprehensive examination would be especially fruitful.
For instance, further examination of DNA methylation could be fruitful.
Examination of specific hypotheses may be fruitful where fewer NTD cases are available, particularly if combined with stratified sample sets in which cases are sub-divided on the basis of phenotype.
Instead, a more fruitful avenue of investigation may be provided by the examination of regions found to be consistently implicated across all three analyses performed, even in cases where this linkage did not reach genome-wide significance (eg, chromosome 2, 6p, 8, 9, 15 and 17. Table 3, Supplementary Figure 1).
The examination of functional modules such as EMT may be a fruitful strategy to identify new neurocristopathy genes.
The list does not represent a comprehensive and exhaustive look at all of the chemical categories found in diesel exhaust, but instead represents a targeted examination of those chemical substances that could potentially lead to fruitful avenues of research.
Examination of these effects in conjunction with multiple sources may offer a fruitful pathway for further understanding.
Should this method prove fruitful in generating informative phenotypes, the combination of the two techniques will allow the examination of gene function throughout all stages of gametophyte development.
Therefore examination of the effect of recently identified risk genes on cognition may prove fruitful in delineating cognitive processes, and by inference neural systems, that may mediate genetic risk.
