Cord blood transplantation should be considered as frontline therapy for young patients with lysosomal and peroxisomal storage diseases.
With continued monitoring of toxicities, a phase Ib/II study of this combination as frontline therapy is warranted.
Rituximab is now routinely recommended during the acute phase, typically in patients with a suboptimal response to treatment, or even as frontline therapy, with high response rates.
The clinical trials of experimental nanomedicine have experienced unexpected adverse effects with modest improvement in efficacy when compared to current frontline therapy.
Although the therapy of patients with DLBCL is an active area of research, the current 5-year overall survival rate is 60 70% using standard-of-care frontline therapy.
Molecular docking on human aromatase, quinone reductase, not on helicase [39], was preferred because it is the popular enzyme in vertebrates known to catalyse the biosynthesis of all oestrogens from androgens and is therefore considered as a frontline therapy for oestrogen-dependent breast cancer [38].
Recently, a panel of global experts in CML deliberated on the imminent approval of second-generation TKIs in the frontline setting, ways to improve on frontline therapy, integration of new agents in current treatment algorithms, and design of future clinical trials; the proceedings of the discussion are summarized in this article.
Relapse after completion of frontline therapy is also common.
These children are removed from the frontline therapy (clinical trial) and are eligible for clinical trials using new therapies.
Many high-risk children have a good response to frontline therapy and achieve a remission, but later the disease recurs (relapse).
It is a high priority drug target, against which monoclonal antibodies (e.g. Herceptin) are used as a frontline therapy.
