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Today's armor systems involve a combination of materials typically including a ceramic or metallic frontal layer followed by multi-layered, fiber reinforced laminates or fabric structures.
Profuse dislocation activity was evident in the frontal layer in the specimen recovered from the projectile impact.
The formation of this frontal layer is proposed to be related to the high lateral confinement, imposed by the surrounding material.
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Deep cortical layers in the frontal cortex (layer V VI) are also the predominant target layers of cortical projections from the BF, which contain more than 70% of axonal varicosities from the BF (Henny and Jones, 2008).
Detailed examination of frontal cortical layer mRNA expression indicated TRPC4 mRNA is distributed throughout layers 2 6 of the prefrontal cortex (PFC), motor cortex (MCx), and somatosensory cortex (SCx).
While strong immunoreactive signal was observed in the perinuclear area of pyramidal cells in frontal cortex layer V, a weak reaction was localized in the cytoplasm of these cells, staining within basal and apical dendrites.
The only reference of Kántor and coauthors [ 24] provides quantitative analysis of total numbers of neurons and neuronal density in the striatum and a part of frontal cortical layer V in groups of 6- and 12-month-old tgHD51 and wt rats.
Despite the fact that tgHD51 rats displayed enlarged lateral brain ventricles, stereological analysis revealed only a subtle decrease in the number of neurons in the striatum, while no changes were observed in number of neurons in the frontal cortical layer V of 12-month-old tgHD51 rats when compared with age-matched wild-type controls [ 24].
Interestingly, an increase was found in the total number of PV-ir neurons in all frontal cortical layers of single transgenic APP mice and in layers II IV of single transgenic PS1ho mice between 2 and 10 months of age.
Finally, in transgenic mice carrying the Swedish (K670M/N671L) mutation of the human amyloid precursor protein, a dramatic increase in cyclin D1 and cyclin A was witnessed between 6 months and 12 months of age in frontal cortical layers V/VI [ 97].
For the delineation of the entire frontal cortex or layers II IV and layers V VI, respectively, a 10× objective was used (UplanApo, NA = 0.40), and for counting PV-ir and CR-ir neurons a 40× oil objective (UplanApo, NA = 1.00).
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