The Frontal Systems Behavior Scale (FrSBe) is a 46-item behavior rating scale that is intended to measure behavior associated with damage to the frontal systems of the brain, with subscales measuring Apathy, Disinhibition, and Executive Dysfunction.
The Frontal Systems Behavior Scale is a rating scale of apathy, disinhibition, and executive function and has demonstrated sensitivity to impairment in an MCI sample [ 70].
All participants were assessed clinically, with a particular emphasis on current and recent impulsive aggressive behavior, frontal lobe function, emotional intelligence and psychosocial adjustment.
Common to most of these subsyndromes is the broad overlap of regions associated with the salience network (anterior cingulate and insula), mood regulation (amygdala), and motivated behavior (frontal cortex).
What is most striking about the data from agitation, depression, apathy, and psychosis in AD is the broad overlap of regions associated with each NPS syndrome, particularly regions known to be associated with the salience network (anterior cingulate and insula), mood regulation (amygdala), and motivated behavior (frontal cortex).
Analogies of this network are found with brain pathways for fight-or-flight and tend-and-befriend behavior, including frontal lobe selection between those two behavioral modes.
As previously described, there is strong evidence for a relationship between criminal behavior and frontal brain malfunctioning.
In addition to deficits in frontal brain functioning, antisocial behavior has also been associated with abnormal activity in specific physiological processes (e.g. Beauchaine et al. 2008; Patrick 2008; Scarpa et al. 2010; Van Goozen et al. 2007).
The partly enlarged MdMNs are thought to control the contraction of the frontal gland during defensive behavior and the latter may be used to close their small mandibles, although this still needs to be demonstrated.
This pattern of results suggested that the functional roles of the NAc and orbital frontal cortex in checking behavior are to control the vigor of motor performance and the focus on goal-directed activity, respectively (Dvorkin et al., 2010).
