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Nicholas Gottardo outlined the COG-proposed front-line trial, a molecularly based stratification-feasibility study for children with newly diagnosed, average-risk medulloblastoma.
To address this, the COG-proposed front-line trial will prospectively evaluate novel diagnostic techniques [ 10, 30, 45], in parallel with established (IHC and FISH) methodologies.
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Lack of effective treatment for patients who progressed on or recurred after front-line therapy allowed trials to avoid obfuscation of OS by post-progression therapy.
In recognition of FX's "American Crime Story: The People v. O.J. Simpson" finale airing Tuesday night, we're digging out some of The Times' front-line coverage of "The Trial of the Century".
What do construction workers, trial lawyers, front-line soldiers, con men and Sam Spade have in common?
Earlier this week, Bedfordshire Police said 60 body cameras would be used by front-line officers following a successful trial.
In addition, the proposed COG front-line average-risk medulloblastoma clinical trial will mandate fresh-frozen tumor tissue.
To this end, the SIOP-E PNET 5-MB study and the proposed COG front-line average-risk medulloblastoma clinical trial will both use central reference laboratories based in Europe and the USA, respectively.
However, Lee et al recently reported the results of a meta-analysis of 23 trials (13 front-line, seven second-line, three maintenance; n=14,570) that evaluated EGFR inhibitors as monotherapy or in combination with chemotherapy.
In the front-line setting, there is a clinical trial exploring the combination of lenalidomide with rituximab bendamustine and other studies looking at the role of lenalidomide maintenance after completion of a rituximab chemotherapy induction.
This cause has special relevance now as state courts are faced with serious cutbacks in financing, forcing some to close their doors one day a week or a month, lay off front-line staff members and delay jury trials.
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